The treatment with N-acetylcysteine of Raynauds phenomenon and ischemic ulcers therapy in sclerodermic patients: a prospective observational study of 50 patients
Clinical Rheumatology, 08/25/2009
Rosata E et al. Long-term therapy with N-acetylcysteine (NAC) in patients with systemic sclerosis (SSc) has a durable effect on ischemic ulcers and Raynaud's phenomenon.Results- Patients had a reduction in the frequency of digital ulcers, digital ulcer VAS, number of attacks of Raynaud's phenomenon, and Raynaud's phenomenon VAS
- There were no adverse effects
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Analysis of rewarming curves in Raynaud's phenomenon of various aetiologies
Journal of Hand Surgery (European Volume), 11/06/2009
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Salem KM et al. – This modified cold provocation test may differentiate between patients with Raynaud's phenomenon, HAVS and controls but this observation requires independent verification in subjects not involved in ... same facility.
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Percutaneous Upper Thoracic Radiofrequency Sympathectomy in Raynaud Phenomenon: A Comparison of T2/T3 Procedure Versus T2 Lesion With Phenol Application
Regional Anesthesia and Pain Medicine, 09/14/2009
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Gabrhelik T et al. – Thoracic RF upper sympathectomy is an effective method in the treatment of resistant forms of Raynaud phenomenon. A single–shot procedure at ... preferable because of the shorter procedure duration of this technique.
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Randomized placebo-controlled crossover trial of tadalafil in Raynaud's phenomenon secondary to systemic sclerosis
Journal of Rheumatology, 09/16/2009
Schiopu Eet al. – Tadalafil appears to be safe and well tolerated but lacks efficacy in comparison to placebo as a treatment for RP secondary to SSc. MethodsResults- 39 subjects completed the study and were evaluable
- No statistically significant differences in Raynaud Condition Score (RCS), frequency of RP episodes, or duration of RP episodes between groups
- Placebo response was confounding factor
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Diagnosis of Raynaud’s Phenomenon by 99mTc-Hydroxymethylene Diphosphonate Digital Blood Flow Scintigraphy After One-hand Chilling
Journal of Rheumatology, 08/19/2009
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Kwon SR et al. – 99mTc–HDP digital blood flow scintigraphy after one–hand chilling is a noninvasive, accurate, and quantitative method to evaluate RP ... medicine,vascular medicine,radiology/diagnostics
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The manifestations of vasculopathy in systemic sclerosis and its evidence-based therapy
International Journal of Rheumatic Diseases, 08/25/2009
Strange G et al. – Review concludes that several manifestations of systemic sclerosis (SSc) including Raynaud's phenomenon, digital ulceration, renal crisis and pulmonary arterial hypertension (PAH) share similarities in their underlying vasculopathy ... has yet demonstrated improvements in overall disease course More robust studies support: - Use of calcium channel blockers for Raynaud's phenomenon, and
- Treatment with bosentan or iloprost for digital ulcers
- For pts with scleroderma renal crisis, ACE inhibitors are the cornerstone
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Prevalence, risk factors and outcome of digital gangrene in 2684 lupus patients
Lupus, 09/21/2009
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Liu A et al. – Long disease duration, Raynaud’s phenomenon and elevated serum CRP were independent predictive factors for SLE to develop digital gangrene. Early and aggressive corticosteroid treatment prevented ... was 33.1 ± 11.8 years and the average disease duration was 99.1 ± 60.1 monthsPatients with SLE, with long disease duration (4 years), Raynaud’s phenomenon and elevated serum C-reactive protein (CRP) were more likely to develop digital gangrene,15 gangrene patients started
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Laser Doppler Perfusion Imaging Is Useful in the Study of Raynaud’s Phenomenon and Improves the Capillaroscopic Diagnosis
Journal of Rheumatology, 09/16/2009
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Rosato E et al. – NVC represents the best method to analyze microvascular damage in rheumatic diseases. LDPI improves the evaluation of vascular damage in patients with ... the definition of the various stages of vascular digital damage in SSc.
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Calcium Channel Blocker Toxicity
Pediatric Emergency Care, 08/20/2009
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to be used for the management of a wide variety of adult and pediatric conditions including hypertension, angina pectoris, atrial arrhythmias, Raynaud phenomenon, and migraine headaches. With increased use comes increased potential for misuse and abuse.
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Radiocephalic Fistula Complicated by Distal Ischemia: Treatment by Ulnar Artery Dilatation
Cardiovascular and Interventional Radiology, 08/12/2009
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Raynaud A et al. – Hand ischemic steal syndrome due to a forearm arteriovenous fistula is a rare occurrence. However, its frequency is increasing with the rise in numbers of elderly and diabetic
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