Top myositis Articles in Rheumatology

Recurrent Orbital Myositis Mimicking Sixth Nerve Palsy: Diagnosis with MR Imaging
American Journal of Neuroradiology, 09/30/2009

Fischer M et al. – The authors present a case with recurrent orbital myositis sequentially affecting both lateral rectus muscles separately. In the first episode, the absence of the required symptoms for the ... myositis led to the erroneous diagnosis of sixth nerve palsy. Eventually, the correct diagnosis was established with cerebral MR imaging. Orbital myositis should be included in the differential diagnosis of what appears clinically to be abducens palsy, and MR imaging with a focus on the orbita is [more...]

All-Trans Retinoic Acid-Induced Focal Myositis, Synovitis, and Mononeuritis
Journal of Clinical Rheumatology (JCR), 10/14/2009

Yu W et al. – Here the authors report a patient with newly diagnosed acute promyelocytic leukemia who developed acute focal myositis, synovitis, and possible vasculitis, after receiving all–trans retinoic acid ... literature on this rare clinical entity, all–trans retinoic acid–induced myositis. This condition can manifest as fever, myalgia, arthralgia, and Sweet syndrome, accompanied by distinct magnetic resonance findings involving the lower extremity musculature. Treatment consists of ... pharmacology,pharmacology/therapy,side effects [more...]

Pathogenic mechanisms of disease in myositis: autoantigens as clues
Current Opinion in Rheumatology, 09/30/2009

Betteridge ZE et al. – There are now a number of models indicating roles of autoantigens in disease pathogenesis. The increased understanding of the autoantigenic properties of these targeted proteins will help to determine ... initiation and propagation of myositis. In turn, these findings may lead to therapeutic advances including the development of more targeted treatments. [more...]

Nonimmune mechanisms of muscle damage in myositis: role of the endoplasmic reticulum stress response and autophagy in the disease pathogenesis
Current Opinion in Rheumatology, 09/30/2009

Henriques–Pons A et al. – Current data indicate that the ER stress, nuclear factor–[kappa]B pathway and autophagy are active in the skeletal muscle of myositis patients, and [more...]

Paraneoplastic myopathy
Current Opinion in Rheumatology, 09/29/2009

Danko K et al. – Cancer–associated myositis differs from primary myositis in many aspects. Prognosis and life–expectancy are determined by the underlying malignancy. Therefore, patient–specific examinations for detection of an underlying cancer are [more...]

Topical Cyclosporine A as a Steroid-Sparing Agent in Steroid-Dependent Idiopathic Ocular Myositis With Scleritis
Eye and Contact Lens: Science and Clinical Practice, 09/18/2009

Gumus K et al. – Topical 0.05% cyclosporine A may be a safe and effective long–term treatment of ocular myositis and scleritis. It should be considered as a steroid–sparing agent [more...]

Voriconazole-Associated Myositis
Journal of Clinical Rheumatology (JCR), 10/22/2009

Shanmugam VK et al. – The authors present a 34–year–old female African American renal transplant recipient, with a prior history of probable statin–induced myopathy, who developed severe generalized weakness with marked elevation of muscle ... increased use of triazoles in immunosuppressed and transplant recipients, it is important for rheumatology consultants to include this entity in their differential diagnosis of weakness in such patients. [more...]

Cumulative organ damage and prognostic factors in juvenile dermatomyositis: a cross-sectional study median 16.8 years after symptom onset
Rheumatology, 09/25/2009

examined, median 16.8 (2.0–38.1) years after disease onset Disease activity measured by disease activity score (DAS), organ damage by the myositis damage index (MDI) and physical function by the childhood or adult HAQ (CHAQ/HAQ) Medical records reviewed for early disease variables [more...]

Exercise as an anti-inflammatory intervention to combat inflammatory diseases of muscle
Current Opinion in Rheumatology, 09/21/2009

Nader GA et al. – In contrast to the previous recommendations to avoid physical exercise, accumulating data now suggest that physical exercise in patients with myositis is safe, benefits clinical outcome and may even reduce inflammation. [more...]

Role of cytokines and chemokines in idiopathic inflammatory myopathies
Current Opinion in Rheumatology, 09/21/2009

for predominance of Th1–mediated reactions in the different IIMs, inflammation–induced degenerative phenomena in inclusion body myositis, and a possible role for lymphoneogenesis in the sustained inflammatory response in dermatomyositis. [more...]