Top lupus Articles in Rheumatology

A clinical and epidemiological study of lupus erythematosus at a tertiary referral dermatology clinic in Korea
Lupus, 12/04/2009

Bae Y et al. – Acute cutaneous lupus erythematosus almost always indicated systemic involvement of lupus erythematosus, whereas chronic cutaneous lupus erythematosus did not predict the ... systemic lupus erythematosus and had a benign clinical course. Careful consideration of lupus erythematosus non–specific skin lesions may help detect systemic lupus erythematosus regardless of the diagnosis of cutaneous lupus erythematosus. [more...]

Ten cases of systemic lupus erythematosus related to hepatitis B vaccine
Lupus, 11/09/2009

Agmon–Levin N et al. – The objective of this article is to identify common and atypical features of systemic lupus erythematosus diagnosed following hepatitis B vaccination. Systemic lupus erythematosus related to ... from idiopathic systemic lupus erythematosus in its clinical presentation and may resemble drug–induced systemic lupus erythematosus. Thus, physicians should be alerted to this potential association, its possible long latency period and unique presentations, and be encouraged to report and ... autoimmune/heritable,systemic lupus (sle) [more...]

Circulating CSF-1 Promotes Monocyte and Macrophage Phenotypes that Enhance Lupus Nephritis
Journal of the American Society of Nephrology, 11/20/2009

Menke J et al. – The found increased levels of CSF–1 in the serum, urine, and kidneys of patients with lupus compared with healthy controls. Serum and urine CSF–1 levels correlated with lupus activity, and intrarenal CSF–1 ... histopathology activity index of lupus nephritis. Circulating CSF–1 is a potential therapeutic target for lupus nephritis. [more...]

Safety of vaccination of patients with systemic lupus erythematosus
Lupus, 11/04/2009

Abu–Shakra M – Vaccines may trigger the generation of autoantibodies which is usually short term and has no clinical significance. In individual cases vaccines exacerbate systemic lupus erythematosus; however, no specific ... identified to be associated with flare of systemic lupus erythematosus following vaccination. [more...]

Sensitivity and specificity of autoantibody tests in the differential diagnosis of lupus nephritis
Lupus, 11/30/2009

Heidenreich U et al. – Testing for anti-nucleosome antibodies and the conventional anti-dsDNA ELISA with lower cut-off provide the best diagnostic aids for differentiation of lupus nephritis from other forms of glomerulonephritis. lupus nephritis in comparison to 43 patients suffering from other forms of glomerulonephritis Results All tests for anti ... considerably increased its sensitivity (87%) without loss of specificity (90%) As anti-histone and Sm antibodies are present only in minority of lupus nephritis patients they are of limited value in diagnosing disease [more...]

Mycophenolate mofetil and intravenous cyclophosphamide are similar as induction therapy for class V lupus nephritis
Kidney International, 11/05/2009

Radhakrishnan J et al. – The authors found that the response to mycophenolate mofetil (MMF) as induction treatment of patients with class V lupus nephritis (LN) appears to be no different from that to intravenous ... pharmacology,glomerular/tubular dz,systemic lupus (sle),pharmacology/kinetics,nephrology [more...]

Infection—genetics relationship in systemic lupus erythematosus
Lupus, 11/05/2009

Sebastiani GD – Evidence has been emerging suggesting that the production of autoantibodies, by infected B–lymphocytes, may be drawn by altered expression of particular microRNA in these cells. In this paper, the authors ... can account for the role of infectious agents, acting on a genetically prone host, in determining systemic lupus erythematosus. [more...]

Regulatory T Cell (Treg) Subsets Return in Patients with Refractory Lupus following Stem Cell Transplantation, and TGF-[beta]-Producing CD8+ Treg Cells Are Associated with Immunological Remission of Lupus
Journal of Immunology, 11/10/2009

Zhang L et al. – Unlike conventional drug therapy, hemopoietic stem cell ... CD8TGF–? Treg cells, which repairs the Treg deficiency in human lupus to maintain patients in true immunological remission. [more...]

Prognostically distinct clinical patterns of systemic lupus erythematosus identified by cluster analysis
Lupus, 11/30/2009

To CH et al. – Patients with systemic lupus erythematosus could be clustered into prognostically distinct patterns of clinical manifestations. Methods Patients divided ... li> Clinical features, prevalence of proliferative lupus nephritis (World Health Organization class III, IV), autoantibody profile, and treatment data compared and standardized mortality ratios calculated for each cluster of patients 1082 patients included in study (mean age at SLE ... but having the lowest prevalence of serositis, hematologic manifestations (hemolytic anemia, leukopenia, and thrombocytopenia), and proliferative lupus nephritis Cluster 2 (n = 409) had mainly renal and hematological manifestations but having lowest prevalence of mucocutaneous manifestations ... Besides having high prevalence of mucocutaneous manifestations, serositis and hematologic manifestations, renal involvement, and proliferative lupus nephritis also most prevalent among 3 clusters Patients in cluster 2 had much higher standardized mortality ratio [standardized mortality ratio ... mortality ratio 0.95 (0.5—1.7), p = 0.86] [more...]

Vaccination, atherosclerosis and systemic lupus erythematosus
Lupus, 11/05/2009

Carvalho JF et al. – In non–systemic lupus erythematosus populations, vaccines against oxidized low–density lipoprotein, beta–2–glycoprotein I, heat shock proteins, lipoproteins, cholesterol, molecules ... receptor, and interleukin–2) have been tested, with promising results. However, there are no studies of vaccination against atherosclerosis in systemic lupus erythematosus. [more...]