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Top amyloidosis Articles in Rheumatology

Vitreous Amyloidosis in Two Sisters as the Indication of Transthyretin-Related Familial Form of Systemic Amyloidosis Among Liver Transplantation Candidates
Transplantation Proceedings, 11/12/2009
Niemczyk R et al. – The authors have presented 2 sisters with involvement of the vitreous body, which prompted a subsequent diagnosis of ... ndash;related, familial form of systemic amyloidosis. Due to the progressive character of the disease and poor prognosis, the patients have been considered for liver transplantation, which at present is the only treatment option for this disease. [more...]

Pulmonary amyloidosis in Sjogren's syndrome: a rare diagnosis for nodular lung lesions
International Journal of Rheumatic Diseases, 11/25/2009
Rodrigues K et al. – Here the authors describe the occurrence of localized amyloidosis presenting as pulmonary nodules in a patient with newly diagnosed SS. The authors highlight this rare occurrence as a ... possibility that should be considered in the evaluation of pulmonary involvement in this disease. [more...]

Left Ventricular Ejection Time on Echocardiography Predicts Long-Term Mortality in Light Chain Amyloidosis
Journal of the American Society of Echocardiography, 11/04/2009
Migrino RQ et al. – AL amyloidosis was associated with high long–term mortality. Among echocardiographic and clinical parameters, only ET and alkaline phosphatase had incremental ... patients. [more...]

Marked shrinkage of amyloid lymphadenopathy after an intensive chemotherapy in a patient with IgM-associated AL amyloidosis
Amyloid The Journal of Protein Folding Disorders, 11/20/2009
Tazawa KI et al. – A male patient with primary AL amyloidosis who had been suffering from systemic lymphadenopathy with IgM?–type M–proteinemia received two ... by autologous peripheral blood stem cell transplantation. Deposits of AL amyloid may regress from the tissue if the chemotherapy succeeds in persistent inhibition of the production of an amyloidogenic immunoglobulin light chain. [more...]

Serum levels of NT-proBNP as surrogate for cardiac amyloid burden: new evidence from gadolinium-enhanced cardiac magnetic resonance imaging in patients with amyloidosis
Amyloid The Journal of Protein Folding Disorders, 11/24/2009
Lehrke S et al. – This study confirms the prognostic value of NT–proBNP in patients with AL and TTR amyloidosis and provides the novel finding that NT–proBNP correlates with surrogates of ... of NT–proBNP as a biomarker reflecting the severity of cardiac amyloid infiltration. [more...]

Amyloid and the GI tract
Expert Review of Gastroenterology & Hepatology, 12/03/2009
Sattianayagam P et al. – In the absence of specific treatments for GI amyloidosis, therapy is aimed at reducing or eliminating the supply of the respective fibril precursor protein. Supportive measures such as nutritional support and antidiarrheal agents should be ... abundance of the fibril precursor protein. GI tract surgery should be performed only if the benefits clearly outweigh the risks, as there is a risk of decompensation of organs affected by amyloid. [more...]

Primary systemic amyloidosis and persistent pleural effusions
Amyloid The Journal of Protein Folding Disorders, 12/01/2009
Schwarz D et al. – The authors report the case of a 73–year–old woman with primary systemic AL and persistent bilateral pleural effusions, refractory to diuresis and repeated thoracenteses. The patient's cardiac and ... was not severe enough to explain these persistent effusions. Thus, despite a lack of biopsy–proven amyloid deposition, we suggest that these effusions may be secondary to pleural amyloid deposition. [more...]

Amyloid arthropathy mimicking seronegative rheumatoid arthritis in multiple myeloma: case reports and review of the literature
Amyloid The Journal of Protein Folding Disorders, 11/18/2009
light chain–immunoreactive amyloid in biopsied tissue and Bence Jones protein in urine. Systemic AL amyloidosis may be important in the differential diagnosis of chronic polyarthralgia. [more...]

Report of five rare or previously unknown amyloidogenic transthyretin mutations disclosed in Sweden
Amyloid The Journal of Protein Folding Disorders, 11/24/2009
mutations have been subjected to liver transplantation, but echocardiographic examination has revealed an increasing cardiomyopathy after transplantation in both cases, the ATTR Leu55Gln patient succumbed 2 years after transplantation from progressive disease. [more...]

Differential affinity of serum amyloid A1 isotypes for high-density lipoprotein
Amyloid The Journal of Protein Folding Disorders, 11/24/2009
Yamada T et al. – The results suggest that the relatively high affinity of SAA1.5 may cause the high serum concentration and may be related to the low susceptibility to amyloidosis. [more...]

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