Top amyloidosis Articles in Rheumatology

Prevention of Amyloidosis in Familial Mediterranean Fever with Colchicine: A Case-Control Study in Armenia
Medical Principles and Practice, 10/05/2009

Sevoyan MK et al. – The study demonstrated that colchicine treatment is effective in preventing amyloidosis among Armenian patients with FMF and that earlier initiation and continuous ... amyloidosis risk among Armenian patients with FMF. Methods The study included 99 Armenian patients from the Center of Medical Genetics database with genetically ascertained FMF; 33 had renal amyloidosis and 66 were randomly selected control patients without renal amyloidosis ... with incident amyloidosis were more likely to be older men, but younger at the time of disease onset, and more likely to have had a family history of amyloidosis and M694F mutation in the MEFV gene compared to patients without amyloidosis. The risk of amyloidosis decreased with adequate ... than interrupted use, earlier rather than later initiation age of colchicine treatment, current colchicine rather than ever/never colchicine use. [more...]

A case with rheumatoid arthritis and systemic reactive AA amyloidosis showing rapid regression of amyloid deposition on gastroduodenal mucosa after a combined therapy of corticosteroid and etanercept
Rheumatology International, 10/16/2009

Ishii W et al. – Systemic reactive amyloid A (AA) amyloidosis is one of the critical complications associated with ... AA amyloidosis patients. This is the first case report of RA–related systemic reactive AA amyloidosis histopathologically demonstrating rapid regression of amyloid deposits on gastroduodenal mucosa after adequate suppression of the underlying inflammatory condition. [more...]

Unusual Combination of Tracheobronchopathia Osteochondroplastica and AA Amyloidosis
Yonsei Medical Journal, 10/29/2009

Kirbas G et al. – This case illustrates that it is possible for TO and amyloidosis to masquerade as asthma. TO and amyloidosis should be suspected in patients of older ages with asthma and especially with ... and lateral tracheobronchial walls are typical for TO, a biopsy should be obtained to exclude amyloidosis. [more...]

Cystatin C is a sensitive marker for detecting a reduced glomerular filtration rate when assessing chronic kidney disease in patients with rheumatoid arthritis and secondary amyloidosis
Scandinavian Journal of Rheumatology, 10/02/2009

Sato H et al. – Serum cysC can identify a reduced GFR more accurately than sCr-eGFRs. Serum cysC > 1.09 mg/L could be a marker of a reduced GFR, and serum cysC > 1.365 mg/L would strongly suggest a reduced GFR in patients who have RA with secondary amyloidosis. 50 patients with RA and secondary amyloidosis (mean age 60.9 ± 11.2 years; 45 women) were evaluated Revised 24-h creatinine clearance (r24-hCCr), was determined by multiplying original value by 0.719, used as reference for GFR Screening potential of serum cysC and ... ROC) curve analyses of reduced GFR, serum cysC gave a greater area under curve than the sCr-eGFR Specificity and PPV 100% when serum cysC > 1.365 mg/L was used [more...]

Effective anti-tnf-î± therapy can induce rapid resolution and sustained decrease of gastroduodenal mucosal amyloid deposits in reactive amyloidosis associated with rheumatoid arthritis
Journal of Rheumatology, 10/09/2009

Kuroda T et al. –This study examined the effect of anti-tumor necrosis factor-? (anti-TNF) therapy in patients with reactive AA amyloidosis associated with RA. Our results indicate a striking ... deposits in gastric mucosal tissue with amelioration of renal functions in patients with reactive amyloidosis due to RA Methods 14 patients with reactive AA amyloidosis associated with RA were prospectively evaluated Mean period of anti-TNF therapy 20.1 ± 13.8 mos [more...]

Classification of amyloidosis by laser microdissection and mass spectrometry based proteomic analysis in clinical biopsy specimens
Blood, 10/09/2009

Vrana JA et al. – LMD/MS identified the amyloid type with 100% specificity and sensitivity in the training set and was conclusive in 98% of the validation set ... enhance our ability to type amyloidosis accurately in clinical biopsy specimens. [more...]

Left Ventricular Ejection Time on Echocardiography Predicts Long-Term Mortality in Light Chain Amyloidosis
Journal of the American Society of Echocardiography, 11/04/2009

Migrino RQ et al. – AL amyloidosis was associated with high long–term mortality. Among echocardiographic and clinical parameters, only ET and alkaline phosphatase had incremental ... patients. [more...]

Localised retroperitoneal amyloidosis mimicking retroperitoneal fibrosis: a rare cause of obstructive uropathy
Singapore Medical Journal, 10/02/2009

Banerji JS et al. – The authors present this case due to the rarity of localised retroperitoneal amyloidosis as a cause of obstructive uropathy. [more...]

Anti-IL-1 treatment for secondary amyloidosis in an adolescent with FMF and Behcets disease
Clinical Rheumatology, 10/06/2009

Bilginer Y et al. – Familial Mediterranean fever (FMF) is associated with mutations in the gene coding for pyrin which lead to accentuated innate immune responses resulting in increased production of ... treatment is beneficial for the suppression of inflammation; however, long–term studies are needed to understand whether progressive renal disease will be prevented. [more...]

MEFV mutations in Egyptian patients suffering from familial Mediterranean fever: analysis of 12 gene mutations
Rheumatology International, 10/16/2009

of V726A gene mutation and the rarity of amyloidosis in this study suggest that Egyptian patients may have a milder form of FMF compared to other populations. The five main founder mutations account for the vast majority of cases of FMF. [more...]