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Salmonella infections in patients with systemic lupus erythematosus: A case series
International Journal of Rheumatic Diseases, 11/25/09

GERONA JG et al. – Systemic lupus erythematosis (SLE) patients are highly susceptible to infections. The goal was to present the experience regarding the manifestations and outcomes of Salmonella infections in a group of Filipino SLE patients.

• Reviewed medical records of Filipino SLE patients with documented Salmonella infection

• Included were 12 patients (11 female), with mean age of 25.75 years (range 11–53 years) and average SLE disease duration 4.45 years to Salmonella infection
• 5 had septic arthritis (knee in 4, hip in 1), 1 of whom had concomitant typhoid fever
• Another 2 patients had typhoid fever only
• Sepsis syndrome noted in 3
• 1 patient each had soft tissue abscess and meningitis
• Salmonella typhi isolated in 7 patients, Salmonella sp. in 4, and S. enteritidis in 1 patient
• 2 patients developed acute respiratory distress syndrome (ARDS), another had mixed Salmonella and Klebsiella pneumonia
• 11 patients were on high-dose steroids for active disease, including 1 patient with antecedent first infusion of cyclophosphamide plus rituximab
• Management consisted of antimicrobials and adjunct surgery for arthritis and abscess
• Except for 3 patients with Salmonella sepsis, all other patients improved with appropriate therapy

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