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See Latest ArticlesEstimation of monocyte-chemoattractantprotein-1 (Mcp-1) level in patients with lupus nephritis
International Journal of Rheumatic Diseases, 11/25/09
ALZAWAWY A et al. – Urinary and not serum MCP-1 is a useful invasive technique for the assessment of renal disease activity in patients with LN.
Methods- 30 patients with SLE (group I): 15 of these patients selected without renal involvement (group I [A]), and the other 15 selected with evidence of renal involvement (group I [B])
- Further 10 age- and sex-matched healthy subjects taken as control group (group II)
- SLE disease activity index (SLEDAI) applied
- Laboratory investigations done for studied group of patients included: renal function tests (antinuclear antibody) titer, (anti-double-stranded DNA) titer, and monocyte chemotactic protein 1 (MCP-1) level in serum and urine samples
- Serum MCP-1 significantly higher in SLE patients with nephritis than in control group, while no significant difference found between SLE patients without nephritis and control group.
- Urinary MCP-1 in patients with active lupus nephritis (LN) significantly higher than both patients with inactive LN and control the group
- Urinary MCP-1 in SLE patients with nephritis significantly higher than both group I (A) and group II
- Urinary MCP-1 correlated positively with proteinuria, and negatively with creatinine clearance and hemoglobin; thus, urinary MCP-1 correlates with severity of nephritis
Today in Basic Science/Genetics...keeping you current
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Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis
Osteoporosis International, 02/09/10
The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population
Arthritis & Rheumatism, 02/09/10
S100A8 and S100A9 in experimental osteoarthritis
Arthritis Research & Therapy, 02/09/10
Today in Systemic Lupus (SLE)...keeping you current
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The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population
Arthritis & Rheumatism, 02/09/10
Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus
Arthritis & Rheumatism, 02/08/10
Expression of High Mobility Group Box Chromosomal Protein 1 and Its Modulating Effects on Downstream Cytokines in Systemic Lupus Erythematosus
Journal of Rheumatology, 02/03/10
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