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Prevalent vertebral deformity independently increases incident vertebral fracture risk in middle-aged and elderly Japanese women: The Japanese Population-based Osteoporosis (JPOS) Cohort Study
Osteoporosis International, 11/25/09

Kadowaki E et al. – Vertebral deformity was associated with a 3-fold increase in subsequent vertebral fracture risk in Japanese women, and this association was stronger in middle-aged women.

• Followed 712 women aged 50–79 years at baseline randomly selected from 3 municipalities in Japan for 6 years
• McCloskey–Kanis criteria identified vertebral deformities on X-ray absorptiometric images
• At follow-up, vertebra with ≥ 20% height reduction from baseline were considered incident fractures
• Rate ratio (RR) of incident fracture for prevalent vertebral deformities calculated using Poisson regression equation adjusted for propensity of having vertebral deformities based on potential risk factors

• Vertebral fractures occurred in 73 women (10.3%)
• Crude RR of vertebral deformity-associated fracture was 4.63 [95% confidence interval (CI), 3.04–7.04] and decreased to 2.96 (95% CI, 1.77–4.94) after propensity score adjustment
• Adjusted RR generally greater in younger women at 7.19 (95% CI, 1.04–49.6), 3.19 (95% CI, 1.27–7.97), and 2.34 (95% CI, 1.33–4.11) for women aged 50–59, 60–69, and 70–79 years, respectively (p=0.0527 for those aged 50–59 vs 70–79)

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