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D Scott Cunningham MD, PhD
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The relation between osteoporosis and vitamin D levels and disease activity in ankylosing spondylitis
Rheumatology International, 08/21/09

Baskan BM et al. – Data suggest that vitamin D deficiency in ankylosing spondylitis (AS) may indirectly lead to osteoporosis by causing an increase in the inflammatory activity; it would be beneficial to monitorize vitamin D levels together with bone mineral density (BMD) measurements in order to determine the patients under osteoporosis risk.

• An investigation of the relation between osteoporosis and vit D and the disease activity in pts with AS
• In 100 AS pts and 58 healthy individuals:
  • Routine blood and urine tests
  • Serum 25-(OH)D3, parathormone (PTH), CRP, ESR
  • Total calcium, ionized calcium, and phosphorous levels
    were measured
• BMD measurements were performed at the anterior–posterior and lateral lumbar and femur regions
• Anterior–posterior and lateral thoracic and lumbosacral radiography was performed on all participants
• The disease activity was evaluated by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)
• Functional status by Bath Ankylosing Spondylitis Functional Index (BASFI)
• Mobility by Bath Ankylosing Spondylitis Metrology Index (BASMI)

• In the patient group, BMD values obtained from the lateral lumbar and femur regions and serum vit D levels were lower than control group
• A negative relation was determined between the lateral lumbar BMD values and ESR, CRP, and BASDAI scores of pts with AS
• The ESR, CRP levels, and BASMI scores of the AS pts with osteoporosis were higher, vs pts w/o osteoporosis
• The negative correlation between serum 25-(OH)D3 level and ESR, CRP levels did not reach a significant level in pts with AS
• The positive correlation between PTH levels and ESR, and the negative correlation between CRP and BASDAI also did not reach a significant level

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