Rheumatology

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Randomized placebo-controlled crossover trial of tadalafil in Raynaud's phenomenon secondary to systemic sclerosis
Journal of Rheumatology, 09/16/09

Schiopu Eet al. – Tadalafil appears to be safe and well tolerated but lacks efficacy in comparison to placebo as a treatment for RP secondary to SSc.

• Prospective, randomized, double-blind, placebo-controlled, crossover study
• Oral tadalafil at a fixed dose of 20 mg daily vs placebo
• Period of 4 weeks
• Women with RP secondary to SSc

• 39 subjects completed the study and were evaluable
• No statistically significant differences in Raynaud Condition Score (RCS), frequency of RP episodes, or duration of RP episodes between groups
• Placebo response was confounding factor
• Tadalafil well tolerated

Today in Clinical Pharmacology...keeping you current

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Effect of alendronate on bone metabolic indices and bone mineral density in patients treated with high-dose glucocorticoid: A prospective study
Osteoporosis International, 11/25/09

Treatment of osteoporosis: Recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivity
Osteoporosis International, 11/25/09

Urinary deoxypyridinoline is a BMD-independent marker for prevalent vertebral fractures in postmenopausal women treated with glucocorticoid
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Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis
Journal of Rheumatology, 11/20/09

The clinical course of polymyalgia rheumatica in Chinese
Clinical Rheumatology, 11/19/09

Evaluation of anti-ribosomal P protein immunoassay in Japanese patients with connective tissue diseases: comparison with an indirect immunofluorescence assay
Scandinavian Journal of Rheumatology , 11/19/09

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Association of mannose-binding lectin gene polymorphisms with Kawasaki disease in the Japanese
International Journal of Rheumatic Diseases, 11/25/09

Serum concentrations of interleukin 1î², cxcl10, and interferon-î³ in mixed cryoglobulinemia associated with hepatitis c infection
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Surgical interventions and local therapy for Wegeners granulomatosis
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