Rheumatology Medical News about giant cell arteritis;expression of glucocorticoid receptor;polymyalgia rheumatica

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Predictors for treatment success and expression of glucocorticoid receptor in giant cell arteritis and polymyalgia rheumatica
Journal of Rheumatology, 09/11/09

Braun N et al. – Expression of GR and the presence of CD20-, CD3-, CD4-, CD8-, CD68-, CD138-positive cells and antigen-presenting cells differ between GCA and PMR. The presence of CD68-positive cells and the extent of GR-staining in chronic inflammation are suitable to predict complete remission in GCA.

Methods

Biopsies of the temporal artery were examined from 60 patients, of whom 27 had GCA, 13 PMR, and 20 arteriosclerosis

Results

Of the clinical variables evaluated, jaw claudication was correlated with the histologic classification of the biopsies
ESR was significantly higher in patients with PMR and GCA than in patients with arteriosclerosis
There were significant differences between patients with GCA versus PMR in the numbers of CD3-, CD8-, and CD4- positive T cells, in CD68-positive monocytes, and antigen-presenting cells
CD138-positive and CD20-positive cells were absent in patients with PMR but present in patients with GCA
In GCA and chronic inflammation most monocytes and lymphocytes expressed GR (88.9%)
The number of CD68-positive cells and the extent of GR-staining in chronic inflammation reflected the success of treatment in logistic regression analysis
GR polymorphism showed that more than 90% of patients had the wild-type (homozygote) of the R23K or N363S polymorphism
There was no evidence that this polymorphism influenced response to treament with GC

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Increase in Age at Onset of Giant Cell Arteritis: A Population-based Study
Annals of Rheumatic Diseases, 11/12/09 Relevance Score: 81%

Giant Cell Arteritis Misdiagnosed as Temporomandibular Disorder: A Case Report and Review of the Literature
Journal of Orofacial Pain, 11/05/09 Relevance Score: 81%

The Operation Was a Success, but the Patient Cannot See
Survey of Ophthalmology, 10/23/09 Relevance Score: 77%

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Cancer Treatment Reviews, 11/05/09 Relevance Score: 67%

Interventions for central giant cell granuloma (CGCG) of the jaws
Cochrane Reviews, 10/27/09 Relevance Score: 67%