Rheumatology Medical News about SLE, Sjogrens syndrome, Treatment

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Emerging new pathways of pathogenesis and targets for treatment in systemic lupus erythematosus and Sjogrens syndrome
Current Opinion in Rheumatology, 08/18/09

Perl A - Review concludes that discovery of novel genes and signaling pathways in lupus pathogenesis offers novel biomarker-targeted approaches for treatment of systemic lupus erythematosus (SLE) and Sjogren's syndrome.

Methods

An evaluation of newly discovered molecular and cellular targets for the treatment of SLE and Sjogren's syndrome

Results

Mammalian target of rapamycin (mTOR) in T and B cells has been successfully targeted for treatment of SLE with rapamycin or sirolimus
Inhibition of below listed pathways showed efficacy in animal models of lupus:
- oxidative stress, nitric oxide production, interferon alpha,
- toll-like receptors 7 and 9, histone deacetylase,
- spleen tyrosine kinase, proteasome function, lysosome function,
- endosome recycling, and the NF-κB pathway
B-cell depletion and blockade of anti-DNA Abs and T-B cell interaction have shown success in animal models as well
However, human studies have so far failed to accomplish clinical endpoints, possibly due to inadequacies in study design

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B cell depletion in lupus and Sjogrens syndrome: An update

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Increased levels of circulating microparticles in primary Sjogrens syndrome, systemic lupus erythematosus and rheumatoid arthritis, and relation with disease activity
Arthritis Research & Therapy, 10/20/09 Relevance Score: 80%

Distinct subtypes of myelitis in systemic lupus erythematosus
Arthritis & Rheumatism, 11/06/09 Relevance Score: 79%

Overactive bladder syndrome in the older woman: conservative treatment
British Journal of Community Nursing, 11/13/09 Relevance Score: 69%

The efficacy of topical thiocolchicoside (Muscoril) in the treatment of acute cervical myofascial pain syndrome: a single-blind, randomized, prospective, phase IV clinical study
Agri, 10/01/09 Relevance Score: 69%

Adult-onset Still’s disease, Schnitzler syndrome, and autoinflammatory syndromes in adulthood
Zeitschrift für Rheumatologie, 10/29/09 Relevance Score: 68%