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rheumatic disease;HMGB1 Article Summary

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HMGB1: An alarmin mediating the pathogenesis of rheumatic disease
Arthritis Research & Therapy, 07/03/08
Print     Email This Article     Save in My Library   Free Abstract
Pisetsky DS et al. - High-mobility group box protein 1 (HMGB1) can play an important role in the pathogenesis of rheumatic disease, including rheumatoid arthritis, systemic lupus erythematosus, and polymyositis among others. New approaches to therapy for these diseases may involve strategies to inhibit HMGB1 release from cells, its interaction with receptors, and downstream signaling.
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