Efficacy of roxithromycin in adult patients with rheumatoid arthritis who had not received disease-modifying antirheumatic drugs: A 3-month, randomized, double-blind, placebo-controlled trial
Clinical Therapeutics, 10/15/2009
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Ogrendik M – It has been reported that antibodies to oral anaerobic bacteria are elevated in the ... rheumatoid arthritis. Macrolide antibiotics are active against oral anaerobic bacteria...In these adult patients with rheumatoid arthritis, 3–month treatment with roxithromycin significantly improved the signs and symptoms of rheumatoid arthritis and was generally well tolerated. Future ... studies should investigate the relationship between disease activity and serum or joint antibodies to anaerobic bacteria.
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Assistive technology for rheumatoid arthritis
Cochrane Reviews, 10/09/2009
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Tuntland H et al. – Provision of assistive technology is a widely used intervention for people with rheumatoid arthritis. Assistive technology is any item used to increase or maintain functional ability in individuals with disabilities. It ... controlled trial with 29 participants was included. The study compared the use of an eye drop device to a standard bottle in people with rheumatoid arthritis suffering from persistent dry eyes. The study was considered to have low quality of evidence. The proportions with observed difficulties when ... assistive technology for adults with rheumatoid arthritis and, therefore, an urgent need for high–quality research addressing the effectiveness of commonly used interventions.
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Certolizumab Pegol: In Rheumatoid Arthritis
BioDrugs, 11/11/2009
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Duggan ST et al. – Certolizumab pegol is a PEGylated humanized Fab? monoclonal antibody that targets and neutralizes both membrane–bound and soluble tumor necrosis factor (TNF)–alpha, preventing inflammation and consequently the ... long elimination half–life of ?2 weeks, allowing subcutaneous administration once every 2 or 4 weeks...In patients with active rheumatoid arthritis who had previously failed to respond to treatment with >=1 disease–modifying anti–rheumatic drug, certolizumab pegol 400 mg every 4 ... in patients with rheumatoid arthritis, with most adverse events being of mild to moderate intensity. Infections were the most frequently reported adverse events.
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Abatacept for rheumatoid arthritis
Cochrane Reviews, 10/09/2009
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Maxwell L et al. – There is moderate–level evidence that abatacept is efficacious and safe in the treatment of rheumatoid arthritis. Abatacept should not be used in combination with other biologics to treat rheumatoid arthritis. The withdrawal and ... modifying anti–rheumatic drugs (DMARDs) or biologics, to placebo or other DMARDs or biologics in patients with moderate to severe rheumatoid arthritis. 2 authors independently assessed search results and risk of bias, and extracted data. The authors obtained adverse event data from ... months in the abatacept group. Serious adverse events were increased when abatacept was given in combination with other biologics
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Treatment of early RA with infliximab is beneficial
American Pharmacists Association, 11/06/2009
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in patients with early rheumatoid arthritis (RA) who did not respond to 3 to 4 months of methotrexate monotherapy.
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Unhealthy Gums Linked to Development of Rheumatoid Arthritis
MedLinePlus, 11/03/2009
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Moderate to severe perodontitis has been linked to the development of rheumatoid arthritis among non–smokers, according to research. Rheumatoid arthritis is a chronic disease that causes pain, stiffness, swelling, and limitation in ... joints. Though joints are the principal body parts affected by RA, inflammation can develop in other organs as well. An estimated 1.3 million Americans have RA, and the disease typically affects women twice as often as men.
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Rheumatoid Arthritis and Tuberculous Arthritis: Differentiating MRI Features
American Journal of Roentgenology, 10/26/2009
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Choi J–A et al. – Uniform synovial thickening, large size of bone erosion, rim enhancement at site of bone erosion, and extraarticular cystic masses were more frequent and more numerous in tuberculous ... arthritis. MRI may be helpful in the differentiation between RA and tuberculous arthritis.
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Relative importance of the functional abilities comprising Health Assessment Questionnaire Disability Index among rheumatoid arthritis patients
Rheumatology International, 10/22/2009
Tuominen R et al. – The aim was to evaluate the relative importance of the 20 functions assessed by patients to produce the Health Assessment ... index computations Methods- Systematic sample of 242 rheumatoid arthritis patients drawn
- Altogether 179 subjects returned acceptably filled questionnaire including perceived rheumatoid arthritis status in 20 functions comprising HAQ-DI
- Separate complementary ... and drying their body
- For both genders least important function was ability to take a tub bath
- Importance of all other functions except taking a tub bath was positively highly significantly correlated with importance of each of other functions
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Corticosteroids Increase Infection Risk in Rheumatoid Arthritis
MedLinePlus, 10/30/2009
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The use of prednisone therapy, especially in high doses, increases the odds that a person with rheumatoid arthritis will develop an infection, according to research.
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Anti-tumor Necrosis Factor Treatment Does Not Increase Cancer Risk In Rheumatoid Arthritis Patients, Study Finds
ScienceDaily, 10/30/2009
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A recent study by Swedish researchers found that rheumatoid arthritis patients did not experience an elevated cancer risk in the first 6 years after starting anti–tumor necrosis factor therapy.
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