Polymyalgia rheumatica and giant cell arteritis
InnovAiT, 09/23/2009
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Knights G – First described in 1888 by William Bruce, a physician practising in Scotland, polymyalgia rheumatica (PMR) is an inflammatory condition of unknown aetiology. Giant cell arteritis (GCA) is a vasculitis of medium or large arteries ... also have PMR), they are thought to share the same underlying pathophysiology, being opposite ends of the same spectrum. Unfortunately, there is no firm evidence to support this.
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Fusobacterium nucleatum Endocarditis Mimicking Polymyalgia Rheumatica
Southern Medical Journal, 10/08/2009
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De Socio GVL et al. – The diagnosis of bacterial endocarditis was delayed because of an insidious presentation, typical in infections with low virulence micro–organisms. An atypical evolution of a common rheumatic disorder such as polymyalgia rheumatica ... alert physicians to the possibility of bacterial endocarditis.
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Polymyalgia rheumatica can recur years after discontinuation of corticosteroid therapy
Clinical and Experimental Rheumatology Online, 09/09/2009
Docken WP et al. – The course of PMR is not uniformly monophasic, and patient and physician should remain alert to the possibility of recurring disease. Methods- 12 patients with recurring ... b>
- Despite a disease-free interval off corticosteroids of 2 years or longer, these patients experienced 1 overt recurrence (or more) of PMR
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Polymyalgia rheumatica prevalence in a population-based sample
Arthritis Care and Research, 09/02/2009
Bernatsky S et al. – These data suggest a higher prevalence of PMR in rural versus urban regions. Methods- Cases were ascertained using physician billing and hospitalization data
Results- This regional trend was also seen in men age 45 years, where the prevalence was estimated at 273.6 cases/100,000 in urban areas and 380.7 cases/100,000 in rural areas
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Predictors for treatment success and expression of glucocorticoid receptor in giant cell arteritis and polymyalgia rheumatica
Journal of Rheumatology, 09/11/2009
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Braun N et al. – Expression of GR and the presence of CD20-, CD3-, CD4-, CD8-, CD68-, CD138-positive cells and antigen-presenting cells differ between GCA and PMR. The ... homozygote) of the R23K or N363S polymorphismThere was no evidence that this polymorphism influenced response to treament with GC
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Familial aggregation in giant cell arteritis and polymyalgia rheumatica: a comprehensive literature review including 4 new families
Clinical and Experimental Rheumatology Online, 09/17/2009
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Liozon E et al. – The survey on familial aggregation of GCA and PMR accumulated data pointing to a genetic predisposition. However, environmental contagious ... in up to one–fourth of the cases.
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Interleukin-12 gene polymorphisim in patients with giant cell arteritis, polymyalgia rheumatica, and elderly-onset rheumatoid arthritis
Clinical and Experimental Rheumatology Online, 09/08/2009
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Alvarez-Rodriguez L et al. – The IL-12 (-1188 A/C 3´UTR) gene polymorphism is not associated with disease susceptibility or severity in three age-related chronic ... were not statistically significant, HC genotypes were associated with distinct IL-12 p70 production
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Clinical, radiological, and biochemical characteristics in patients with diseases mimicking polymyalgia rheumatica
Clinical Interventions in Aging, 10/01/2009
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Yanai H et al. – Pseudogout, RS3PE syndrome, post–infectious polyarthritis should be included in the spectrum of diseases mimicking PMR. A promptly decreased serum CRP ... polyarthritis from PMR. Pitting edema of the back of hands and symmetric gallium uptake in MCP joints are characteristic for RS3PE syndrome.
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The clinical course of polymyalgia rheumatica in Chinese
Clinical Rheumatology, 11/19/2009
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Li WL et al. – The aim of this study was to examine the clinical characteristics of PMR patients in a Chinese cohort compared to a Caucasian series. Chinese patients with PMR have modestly different clinical profile compared to the ... and anti–CCP antibodies were more likely to be present in those who subsequently developed into RA.
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Elderly Onset Rheumatoid Arthritis: Differential Diagnosis and Choice of First-Line and Subsequent Therapy
Drugs & Aging, 09/08/2009
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ndash; The differential diagnosis of EORA from other rheumatological disorders that are prevalent in this stratum of the population, such as polymyalgia rheumatica, crystal–induced arthritis or osteoarthritis, may be complicated because these disorders can present with signs and symptoms
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