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Interleukin-12 gene polymorphism and cervical cancer risk
American Journal of Clinical Oncology, 10/06/09

Tamandani K et al. – This is the first study to provide an evidence for the association of IL-12&beta (1188A/C) gene polymorphism with the risk of cervical cancer.

Methods

DNA isolated from peripheral blood of 200 patients with cervical cancer and 200 healthy controls
Polymerase chain reaction restriction fragment length polymorphism used for detection of IL-12 &beta (1188A/C) gene polymorphism

Results

Was observed that genotypes AC increase the risk of cervical cancer
Strength of risk in passive smokers with AC and AC + CC genotypes increased to more than 2.8 times in comparison with nonsmoker with AA genotype