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Down-regulation of GRP78 Enhances Chemotherapy Sensitivity to VP-16 in Lung Adenocarcinoma
Chinese Journal of Lung Cancer, 11/25/09
Jiang L et al. – BAPTA–AM is highly effective in the inhibition of GRP78, down–regulation of GRP78 can significantly increase the sensitivity of adenocacinoma lung cancer to VP–16. All these suggest that inhibition of the expression of GRP78 by chemicals such as BAPTA–AM or anti–sense RNA may be a new therapeutic strategies to lung cancer.
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