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Docetaxel first-line therapy in HER2-negative advanced breast cancer: a cohort study in patients with prospectively determined HER2 status
Anti-Cancer Drugs, 10/16/09

Gonçalves A et al. – Docetaxel is one of the most active cytotoxic drugs against breast cancer, but data are lacking on specific activity in molecularly selected subgroups. This retrospective study was aimed at assessing the outcome and prognostic factors for survival of patients with HER2-negative tumors receiving first-line docetaxel-based chemotherapy for advanced breast cancer. After multivariate analysis, only three independent variables for PFS (HR-positive tumor, no prior adjuvant/neoadjuvant chemotherapy, and isolated bone metastases) and two for OS (HR-positive tumor and isolated bone metastases) remained predictive of a favorable outcome.

Methods

Medical charts of 162 patients with prospectively proven HER2-negative ABC and having received docetaxel as first-line chemotherapy for metastatic disease retrospectively reviewed
Special emphasis on docetaxel efficacy
Potential prognostic factors sought using multivariate analysis
Median PFS 12 months and median OS was 34.9 months

Results

Median PFS 12 months and median OS 34.9 months
Hormone receptor (HR) status was strongest prognostic factor in univariate analysis for both PFS and OS
After multivariate analysis, only 3 independent variables for PFS (HR-positive tumor, no prior adjuvant/neoadjuvant chemotherapy, and isolated bone metastases) and 2 for OS (HR-positive tumor and isolated bone metastases) remained predictive of a favorable outcome