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See Latest ArticlesOverexpression of p53 is correlated with poor outcome in premenopausal women with breast cancer treated with tamoxifen after chemotherapy
Breast Cancer Research and Treatment, 10/12/09
Kimet HS et al. – Overexpression of p53 is significantly associated with tamoxifen resistance in premenopausal women with breast cancer.
Methods- Data from 4,683 patients with cancer enrolled in two institutions between 1997 and 2006 analyzed
- Analyzed correlation between p53 overexpression and relapse, response to adjuvant therapy, breast cancer-specific survival (BCSS), and RFS in patients with primary breast cancer
- Overexpression of p53 was noted in 1,091 patients
- Significant correlation existed between p53 overexpression and poor prognostic factors, an increased frequency of regional recurrence, visceral metastasis, and worse BCSS and RFS
- Based upon subgroup analyses, combined age (<35, 35–50, and >50 years) and adjuvant therapy (hormone therapy only, chemotherapy only, and hormone therapy following chemotherapy), greatest reduction of survival based on p53 overexpression noted in patients 35–50 years of age who received hormone therapy following chemotherapy
- Multivariate analysis showed that p53 overexpression is independent prognostic factor in patients treated with hormone therapy and chemotherapy
- p53-overexpressing patients with breast cancer between 35 and 50 years of age who received tamoxifen following chemotherapy had greatest adverse effect on outcome
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