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Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction
Proceedings of the National Academy of Sciences of the United States of America, 06/10/09
Goldstein RZ et al. - ACC hypoactivations in drug users cannot be attributed to task difficulty or disengagement. Nevertheless, emotional salience modulates ACC responses in proportion to drug use severity. Interventions to strengthen ACC reactivity or interconnectivity may be beneficial in enhancing top-down monitoring and emotion regulation as a strategy to reduce impulsive and compulsive behavior in addiction.
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