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Combination treatment with varenicline and nicotine replacement therapy
Nicotine & Tobacco Research, 04/10/09
Ebbert JO et al. - These findings suggest that combination therapy with varenicline and NRT is safe and well tolerated among patients in a residential tobacco treatment program.
Methods- Reviewed the clinical experience of two groups of cigarette smokers enrolled in a residential tobacco treatment program: (a) patients receiving combination treatment with varenicline and NRT (N = 104) and (b) usual-care patients receiving treatment before the release of varenicline (N = 135).
- Demographic characteristics were similar between the two groups
- Among smokers receiving varenicline and NRT, 71% used the nicotine patch with a mean dose of 32 mg/day (SD = 14) and 73% used at least two types of NRT.
- Adverse events were experienced by 39% (95% CI = 31%–49%) of patients receiving varenicline and NRT and by 59% (95% CI = 51%–67%) of usual-care patients during the residential program.
- A total of five patients (5%) discontinued varenicline due to adverse events, compared with one patient in the usual-care group.
- We did not observe a significant difference in the 30-day point prevalence smoking abstinence rate at 6 months between patients treated with varenicline and NRT (54%; 95% CI = 44%–64%) and usual-care patients (59%; 95% CI = 50%–66%).
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