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Memantine Dosing in Patients With Dementia
American Journal of Geriatric Psychiatry, 03/09/09

Dolder C et al. - Appropriate dosing of memantine in patients with dementia is important in an effort to maximize the medication's safety and efficacy.

Methods

Retrospective study was conducted involving patients, admitted over a 2-year-period, with a diagnosis of dementia and receiving memantine.
Published clinical trials, pharmacokinetic studies, and clinical trial registry data were used to investigate relationships among dose, efficacy, and side effects.

Results

Of the 70 patients comprising the study sample, 27% were not prescribed appropriate doses of memantine at the time of admission.
60% of those patients who should had memantine renally dose-adjusted were not prescribed the adjusted dose.
Trial and pharmacokinetic data support the need to renally adjust memantine.

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