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The first- and second-generation antipsychotic drugs affect ADP-induced platelet aggregation
World Journal of Biological Psychiatry, 12/22/08
Dietrich-Muszalska A et al. - The obtained results indicate that antipsychotic drugs, especially clozapine and olanzapine, contrary to haloperidol, reduced response of blood platelets to ADP measured as platelet aggregation. This suggests that therapy with such antipsychotics, particularly with second-generation antipsychotics, may partly reduce prothrombotic events associated with the increased platelet activation observed in schizophrenic patients.
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