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Methamphetamine disrupts blood–brain barrier function by induction of oxidative stress in brain endothelial cells
Journal of Cerebral Blood Flow & Metabolism, 08/20/09
Ramirez SH et al. – The data suggest that BBB injury is caused by METH–mediated oxidative stress, which activates MLCK and negatively affects the TJ complex. These observations provide a basis for antioxidant protection against brain endothelial injury caused by METH exposure.
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