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See Latest ArticlesIdentification of Novel Small-Molecule Agonists for Human Formyl Peptide Receptors and Pharmacophore Models of their Recognition
Molecular Pharmacology, 11/25/09
Kirpotina LN et al. – Molecular modeling of the group of FPR1 and FPR2 agonists using field point methodology allowed us to create pharmacophore models for ligand binding sites and formulate requirements for these specific N–formyl peptide receptor agonists. These studies further demonstrate that agonists of FPR1/FPR2 include compounds with wide chemical diversity and that analysis of such compounds can enhance the understanding of their ligand/receptor interaction.
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