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Oral Metoclopramide as an Adjunct to Analgesics for the Outpatient Treatment of Acute Migraine
Annals of Pharmacotherapy, 02/29/08

Azzopardi TD et al. - Combinations containing oral metoclopramide plus an analgesic may be an option for patients in whom triptans are contraindicated or who experience intolerable adverse effects, or when cost is an issue. However, patients and physicians should be aware that the combination will likely be less effective than oral triptans in treatment of migraine and its associated symptoms. To determine the role of combination therapy that includes oral metoclopramide in mild-to-moderate migraines, further studies are warranted.

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