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Nikbakh MR et al. - Considering the fact that the patients in this study had been resistant to standard treatment, trazodone might be a suitable alternative for management of children with PNE. According to our best knowledge, this is the first experience with trazodone in the treatment of enuresis. Limitations of this study include the small number of cases, lack of serum drug level controls and the open label design. In conclusion, our findings demonstrated that trazodone appears to be a promising new approach for the treatment of children with PNE

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