Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. 2008 Exclusive Survey—Earnings: Good news for primary care income 3. Medicare pay-for-reporting effort draws fire from frustrated doctors 4. Debunking Myths in the US Healthcare System 5. Statins and cancer risk
Your Article Summary
Exonuclease Removal of Dideoxycytidine (Zalcitabine) by the Human Mitochondrial DNA Polymerase
Antimicrobial Agents and Chemotherapy, 01/17/08
Hanes JW et al. - In addition, we provide a more accurate measurement of the rate of excision and show that the low rate of removal of ddCMP results from both the unfavorable transfer of the primer strand from the polymerase to the exonuclease site and the inefficient binding and/or hydrolysis at the exonuclease site. The analogs ddC, stavudine, and ddATP (a metabolite of didanosine) each bind more tightly at the polymerase site during incorporation than normal nucleotides, and this tight binding contributes to slower excision by the proofreading exonuclease, leading to increased toxicity toward mitochondrial DNA
| Previous Article | Next Article |
Today in Antimicrobials...keeping you current
Receive free subspecialty "5-minute updates" via email
Empiric Antimicrobial Therapy for Pediatric Skin and Soft-Tissue Infections in the Era of Methicillin-Resistant Staphylococcus aureus
Pediatrics, 05/27/09
Caspofungin for the treatment of candidaemia in patients with haematological malignancies
Clinical Microbiology and Infection, 06/29/09
Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998-2004
BMC Pediatrics, 06/25/09
Article Search
Sponsor


See Latest Articles


