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Carvedilol increases ciclosporin bioavailability by inhibiting P-glycoprotein-mediated transport
Journal of Pharmacy and Pharmacology, 10/12/07

Amioka, K., et al. - Carvedilol is often used to treat hypertension and for prophylaxis in vascular sclerosis in renal transplant recipients, who require concomitant treatment with ciclosporin. However, there are few reports regarding the pharmacokinetic interactions between carvedilol and ciclosporin. We have investigated the potential effects of carvedilol on the pharmacokinetics of ciclosporin, and examined the inhibitory effects of carvedilol on P-glycoprotein-mediated transcellular transport using Caco2 cells

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Pharmacokinetics of fentanyl after subcutaneous administration in volunteers
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Pharmacokinetics and its relation to toxicity of pegylated-liposomal doxorubicin in chinese patients with breast tumours
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