Determinants of Vaccine Immunity in the Cohort of Human Immunodeficiency Virus-Infected Children Living in Switzerland
The Pediatric Infectious Disease Journal, 10/14/2009
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Myers C et al. – All pediatricians in charge of HIV–infected children are urged to identify missing immunizations in this high–risk population.
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Structure-Function Analysis of Human Immunodeficiency Virus Type 1 gp120 Amino Acid Mutations Associated with Resistance to the CCR5 Coreceptor Antagonist Vicriviroc
Journal of Virology, 11/19/2009
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Ogert RA et al. – The cumulative results of this study suggest that as the RU570 VCV–resistant virus adapted to use the ... developed an increased reliance on the N terminus of CCR5.
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Dermatological aspects of medicine: highly active antiretroviral therapy and the treatment of human immunodeficiency virus
Clinical and Experimental Dermatology, 10/05/2009
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Finucane KA et al. – The regimens of drug treatments and the more common side–effects including HIV–lipodystrophy syndrome will be discussed along with the recommendations for testing of people for HIV from new guidelines.
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Improvement of an ultrasensitive human immunodeficiency virus Type 1 real-time reverse transcriptase–polymerase chain reaction targeting the long terminal repeat region
Transfusion, 11/20/2009
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Edelmann A et al. – Human immunodeficiency virus Type 1 (HIV–1) assays applying nucleic acid testing (NAT) rely on ... limited or abolished by genetic polymorphisms occurring in the target sequence. Surveillance of HIV–1 genetic diversity is essentially required to continually evaluate its impact on performance of diagnostic and patient monitoring assays.
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Oral Fluid Tests for Screening of Human Immunodeficiency Virus-Exposed Infants
The Pediatric Infectious Disease Journal, 11/12/2009
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Sherman GG et al. – In high human immunodeficiency virus prevalence settings, routine screening of infants attending immunization visits could improve identification of HIV–exposed infants to receive an ... demonstrates a sensitivity of <90% for detection of HIV–exposure resulting in failure to detect at least 1 in 10 HIV–infected infants.
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A Quantitative Affinity-Profiling System That Reveals Distinct CD4/CCR5 Usage Patterns among Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Strains
Journal of Virology, 10/12/2009
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Johnston SH et al. – The application of the vector metrics also indicated that envelopes derived from elite suppressors ... infected viremic progressors. The affinity–profiling system may help to refine studies of R5 virus tropism and pathogenesis.
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Myopericytoma in Patients With AIDS: A New Class of Epstein-Barr Virus-associated Tumor
American Journal of Surgical Pathology, 10/27/2009
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Lau PPL et al. – The authors report 2 cases occurring in patients with acquired immunodeficiency syndrome who show unusual clinical and biologic features. One patient presented with a bronchial mass and the other developed mass lesions of ... vascular spaces. Focally, these areas merged into fascicles of more elongated cells with eosinophilic cytoplasm. This tumor type therefore also broadens the spectrum of neoplasms associated with EBV.
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Chemokines and common variable immunodeficiency; possible contribution of CCL19, CCL21 and CCR7 to immune dysregulation
Clinical and Experimental Immunology, 10/05/2009
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Fevang B et al. – CVID patients have raised circulatory levels of CCL19 and CCL21, and an attenuated cytokine response to stimulation with these chemokines. Because CCR7 ... mediators balancing immunity and tolerance in the immune system, the abnormalities of these mediators might contribute to the profound immune dysregulation seen in CVID.
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Strengthening families to support children affected by HIV and AIDS
AIDS Care, 10/01/2009
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families and prevent knock–on negative outcomes through programmes such as home visiting, and protection and enhancement of children's potential through early child development efforts.
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CD46-induced human Treg enhance B-cell responses
European Journal of Immunology, 10/06/2009
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a subset of CD46–deficient patients, who present with common variable immunodeficiency. Thus, the lack of cTreg function in optimizing B–cell responses could explain why some CD46–deficient patients develop common variable immunodeficiency.
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