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Preferential reduction of bone mineral density at the femur reflects impairment of physical activity in patients with low-activity rheumatoid arthritis
Modern Rheumatology, 11/25/09
Sugiguchi S et al. – A muscle tonus has more effect than weight-bearing activity on BMD in patients with RA. BMD of the femoral neck is a useful index for general evaluation of RA patients.
Methods- BMD of the lumbar spine, femur, and distal radius was measured in 105 female patients with well-controlled RA.
- The RA patients showed a greater decrease in BMD of the femoral neck than of the lumbar spine.
- Age, Health Assessment Questionnaire (HAQ) score, and Larsen damage score had negative correlations with BMD of the femoral neck.
- In multiple regression analysis of the parameters associated with BMD of the femoral neck in simple regression analysis, an increase in HAQ score showed a negative correlation with BMD of the femoral neck.
- After initiation of treatment with alendronate (ALN), BMD of the femoral neck increased and correlated with improvement in HAQ score.
- A decrease in BMD of the femoral neck is a characteristic of RA.
Today in Arthritis/Rheumatology...keeping you current
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Today in Bone Metabolism...keeping you current
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