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See Latest ArticlesExpression analysis of human pterygium shows a predominance of conjunctival and limbal markers and genes associated with cell migration
Molecular Vision, 11/25/09
Jaworski CJ et al. – The expression pattern of keratins and other markers in pterygium most closely resemble those of conjunctival and limbal cells; some corneal markers are present, notably Krt12, but at lower levels than equivalent conjunctival markers. These data are consistent with the model of pterygium developing from the migration of conjunctival– and limbal–like cells into corneal epithelium. Identification of genes with roles in cell migration suggests potential therapeutic targets. In particular, the ability of polyamine analogues to reduce migration in primary cultures of pterygium presents a possible approach to slowing pterygium growth.
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