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See Latest ArticlesNew lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia
Journal of Clinical Oncology, 10/12/09
Tiu RV et al. – SNP-A analysis allows enhanced detection of chromosomal abnormalities and provides important prognostic impact in AML.
Methods- 250K and 6.0 SNP-A analyses on 140 patients with primary (p) and secondary (s) AML
- Correlated results with clinical outcomes and Flt-3/nucleophosmin (NPM-1) status
- SNP-A is more sensitive than MC in detecting unbalanced lesions
- )Acquired somatic UPD, not detectable by MC, was common in our AML cohort
- Patients with SNP-A lesions including acquired somatic UPD exhibited worse overall survival (OS) and event-free survival (EFS) in pAML with normal MC and in pAML/sAML with abnormal MC
- SNP-A improved predictive value of Flt-3 internal tandem duplication/NPM-1 status, with inferior survival seen in patients with additional SNP-A defects
- Multivariate analyses confirmed independent predictive value of SNP-A defects for OS and EFS
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