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High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition
BMC Cancer, 11/16/07

Klein-Scory, S., et al. - Our results show that Smad4-mediated tumor suppression in cervical cancer cells is not due to restoration of TGF-beta growth inhibitory responses. Rather, tumor cell ECM interactions may be more relevant for Smad4-mediated tumor suppression. C4-II cells with high level inducible Smad4 expression may serve as a model to indicate further Smad4 targets responsive to diverse environmental stimuli operative in vivo

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