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Cigarette smoking is an independent risk factor for cervical intraepithelial neoplasia in young women: A longitudinal study
European Journal of Cancer, 10/15/09

Collins S et al. – Current smoking intensity is an independent risk factor for high-grade CIN in young women, after controlling for cervical HPV infection.

• Longitudinal analysis
• 1485 women aged 15–19 y
• 1075 HPV-negative and cytologically normal at recruitment
• 410 HPV-positive, cytologically abnormal or both
• Women re-attended every 6 mos, when samples were taken for cytological and virological examination

• Current smoking intensity associated with increased risk of high-grade CIN, after controlling for cervical HPV status
• In those HPV-negative and cytologically normal at recruitment, current smoking not significantly associated with risk of acquiring cervical HPV infection, after controlling for life-time number of partners and age of oldest partner (HR=1.13, 95% CI 0.90–1.41); nor did it prolong length of time during which HPV could be detected

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