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Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen
Cochrane Reviews, 10/09/09

Chin J et al. – Tamoxifen is commonly used by women to reduce the risk of breast cancer recurrence. Tamoxifen can also cause abnormal changes to the lining of the womb (endometrium), including polyps and cancer...The Mirena LNG–IUS appears to prevent the development of benign endometrial polyps in breast cancer patients taking tamoxifen, over a one–year period. There is no clear evidence from the available randomised controlled trials that LNG–IUS prevents endometrial hyperplasia or adenocarcinoma in these patients. Larger studies are necessary to assess the effects of LNG–IUS in preventing endometrial hyperplasia and endometrial cancer, and to determine whether LNG–IUS might have an impact on the risk of breast cancer recurrence.

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Systematic Review: Comparative Effectiveness of Medications to Reduce Risk for Primary Breast Cancer
Annals of Internal Medicine, 11/17/09 Relevance Score: 81%

Levonorgestrel-releasing intrauterine device insertion ameliorates leiomyoma-dependent menorrhagia among women of reproductive age without a significant regression in the uterine and leiomyoma volumes
Fertility and Sterility, 11/11/09 Relevance Score: 80%

Rapid noninvasive optical imaging of tissue composition in breast tumor margins
The American Journal of Surgery, 10/07/09 Relevance Score: 80%

Temporal and regional trends in IUD insertion: a population-based study in Ontario, Canada
Contraception, 10/19/09 Relevance Score: 78%

Low-dose tamoxifen in the treatment of breast ductal intraepithelial neoplasia: Results of a large observational study
Annals of Oncology, 10/29/09 Relevance Score: 70%