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The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia
Cancer Causes and Control, 10/02/09

Hwang JH et al. – Our findings suggest that the dietary intake of vegetables and fruits is associated with the progression of cervical carcinogenesis.

• 1,096 women aged 18–65 to participate in a HPV cohort study from March 2006 up to present
• 328 HPV-positive women (166 controls, 90 CIN I and 72 CIN II/III).
• Multivariate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) estimated by multinomial logistic methods

• Higher HPV viral load was associated with an increased risk of CIN I (OR = 2.68, 95% CI, 1.19–6.04) and CIN II/III (OR = 2.78, 95% CI, 1.15–6.72)
• )Relationships between HPV infection, dietary intake of vegetables and fruits and risk of CIN not statistically significant
• Subjects with lower intake of vegetables and fruits, and higher viral load (?15.5) have higher risk of CIN II/III compared with subjects with lower intake of vegetables and fruits, and lower viral load

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