Top hpv Articles in Ob/Gyn

FDA Approves Gardasil to Prevent Genital Warts in Males. Agency Also Approves Bivalent HPV Vaccine for Girls, Young Women
American Family Physician, 10/27/2009

The FDA has expanded its approval of Merck & Co. Inc.'s quadrivalent human papillomavirus, or HPV, vaccine, which is marketed as Gardasil, to include use of the vaccine to prevent ... up to a bivalent HPV vaccine for girls and young women. During clinical trials in more than 4,000 males, Gardasil was nearly 90 percent effective in preventing genital warts caused by infection with HPV types 6 and 11. Gardasil was approved in 2006 for use in girls and young women ages 9–26 years ... caused by HPV types 16 and 18; genital warts caused by HPV types 6 and 11; and precancerous or dysplastic lesions caused by HPV types 6, 11, 16, and 18. Merck's vaccine soon will have competition from GlaxoSmithKline Biologicals, or GSK. The FDA approved GSK's bivalent HPV vaccine, Cervarix, on Oct ... the prevention of cervical cancer and precancerous lesions caused by HPV types 16 and 18 in girls and women ages 10–25. [more...]

Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia
New England Journal of Medicine, 11/06/2009

Kenter GG et al. – Clinical responses in women with HPV-16–positive, grade 3 vulvar intraepithelial neoplasia can be achieved by vaccination with a synthetic long-peptide vaccine against the HPV-16 oncoproteins E6 and E7 ... be correlated with induction of HPV-16–specific immunity. Methods Immunogenicity and efficacy of a synthetic long-peptide vaccine in women with HPV-16–positive, high-grade vulvar intraepithelial neoplasia investigated 20 women with HPV-16–positive, grade 3 vulvar ... 3 or 4 times with mix of long peptides from HPV-16 viral oncoproteins E6 and E7 in incomplete Freund's adjuvant End points were clinical and HPV-16–specific T-cell responses Results Most common adverse events were local swelling in 100% of patients and fever in ... confidence interval [CI], 36 to 81) had clinical responses and reported relief of symptoms 5 women had complete regression of lesions, and HPV-16 was no longer detectable in 4 of them At 12 months of follow-up, 15 of 19 patients had clinical responses (79%; 95% CI, 54 to 94), with [more...]

HPV: Past, present, and in practice: The Omnia CME Journal
The Journal of Family Practice, 11/02/2009

Wright Jr TC et al. – This supplement addresses some important issues regarding human papillomavirus (HPV) and its effect on women. Even though most clinicians have a general understanding of the natural history of HPV and HPV DNA ... testing, many are using HPV DNA testing inappropriately. In addition, the knowledge base on HPV keeps expanding with well–validated, molecular tests that determine which women are infected with highrisk types of HPV. More news is available on a highly effective vaccine that prevents infection ... high–risk types of HPV—HPV 16 and 18. This volume of The Omnia CME Journal is titled “HPV: Past, present, and in practice.” Dr Thomas Wright’s article focuses on what we have recently learned about the natural history of HPV infections. The second is a reprint of a recent Clinical Update from ... Colposcopy and Cervical Pathology (ASCCP) on HPV assays. The third by Dr Barbara Levy is an article on implementing HPV vaccination in your office. All 3 are focused with the intent of providing you with key clinical points in an easy–to–digest format. [more...]

Cigarette smoking is an independent risk factor for cervical intraepithelial neoplasia in young women: A longitudinal study
European Journal of Cancer, 10/15/2009

grade CIN in young women, after controlling for cervical HPV infection. Methods Longitudinal analysis 1485 women aged 15–19 y 1075 HPV-negative and cytologically normal at recruitment 410 HPV-positive, cytologically abnormal or both Women re ... increased risk of high-grade CIN, after controlling for cervical HPV status In those HPV-negative and cytologically normal at recruitment, current smoking not significantly associated with risk of acquiring cervical HPV infection, after controlling for life-time number of partners and age ... length of time during which HPV could be detected [more...]

Human papillomavirus vaccination in survivors of childhood cancer
Cancer, 10/12/2009

is now available to prevent human papillomavirus (HPV), the most common sexually transmitted infection and the cause of cervical cancer, which is the second most common cancer among women worldwide. The purpose of this article was to describe the HPV vaccine and its usefulness in the survivorship ... cancer survivors as being at increased risk for HPV complications, identify factors associated with HPV vaccination, and discuss the utilization of these predictors in designing strategies to promote adherence to HPV vaccination recommendations within the survivorship context. [more...]

Human papillomavirus infection in Beijing, People's Republic of China: a population-based study
British Journal of Cancer, 10/01/2009

Zhao R et al. – HPV 16, HPV 58 and HPV 33 were the most prevalent HPV types in Beijing, indicating the potential for the prophylactic HPV 16/18 vaccine in China. [more...]

Simultaneous Chlamydia trachomatis and HPV infection in pregnant women
Diagnostic Cytopathology, 10/30/2009

Pereira SMM et al. – Pregnancy is associated with HPV infection and with Chlamydia trachomatis (CT) infection mostly due to the natural immunosuppression. The high rate of simultaneous CT and HPV infection in pregnant women favors the ... pregnant women for both CT and HPV. [more...]

Innovation in Cervical Cancer Prevention and Control in Mexico
Archives of Medical Research, 10/26/2009

includes primary prevention with HPV vaccination for girls aged between 12 and 16 years (before sexual initiation), Pap testing with excellent quality control for women 24–34 years of age and high–risk HPV DNA testing for women 35 years and older. HPV samples would be either clinically ... women with positive HPV test results would receive follow–up high–quality Pap testing. This approach is creative and focuses on reducing disparities and providing high–quality care that is also cost effective. [more...]

Is use of the HPV vaccine among female college students related to HPV knowledge and risk perception
Sexually Transmitted Infections, 10/22/2009

Licht AS et al. – The findings suggest knowledge deficits and misperceptions about HPV risk as potential themes for educational campaigns encouraging greater use of the preventive HPV vaccine [more...]

The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia
Cancer Causes and Control, 10/02/2009

Hwang JH et al. – Our findings suggest that the dietary intake of vegetables and fruits is associated with the progression of cervical carcinogenesis ... HPV cohort study from March 2006 up to present 328 HPV-positive women (166 controls, 90 CIN I and 72 CIN II/III). Multivariate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) estimated by multinomial logistic methods Results Higher HPV ... with an increased risk of CIN I (OR = 2.68, 95% CI, 1.19–6.04) and CIN II/III (OR = 2.78, 95% CI, 1.15–6.72) )Relationships between HPV infection, dietary intake of vegetables and fruits and risk of CIN not statistically significant Subjects with lower intake of vegetables and fruits [more...]