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See Latest ArticlesEffect of Ethanol on the Release of Morphine Sulfate From Oramorph SR Tablets
American Journal of Therapeutics, 11/20/09
Barkin RL et al. – Regardless of ethanol concentration, ethanol exposure did not increase the rate of release of morphine sulfate. Release of approximately 20%–25% of the morphine sulfate dose within 1 hour was consistent among the morphine doses tested and ethanol concentrations. Release of morphine sulfate from the 60– and 100–mg tablets exposed to the higher ethanol concentrations (20% and 40% ethanol) was slightly delayed at all time points beyond 1 hour. The results of this in vitro study suggest that ethanol concentrations as high as 40% do not substantially alter the sustained–release properties of the morphine sulfate tablets.
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