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Post-transcriptional control of neurofilaments: New roles in development, regeneration and neurodegenerative disease
Trends in Neurosciences, 11/25/09
Szaro BG et al. – Recent studies have shown that post–transcriptional mechanisms modulate increases in NF gene transcription during axon regeneration to yield the final pattern of NF protein expression. Other recent work has found that post–transcriptional control of NFs shares elements with that of other axonal proteins and that its dysregulation contributes to amyotrophic lateral sclerosis. Such studies herald a novel approach to understanding how neurons coordinate the expressions of functionally related proteins and provide new insights into how the dysregulation of this control can lead to disease.
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