Neurology Medical News about neuroblastome tumors;MYCN amplification

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Centrosome amplification is correlated with ploidy divergence, but not with MYCN amplification, in neuroblastoma tumors
Cancer Genetics and Cytogenetics, 12/31/08

Fukushi D et al. – Findings suggest that different mechanisms may generate centrosome amplification in cells of infant vs childhood diploid tumors; MYCN amplification was not correlated with centrosome amplification in sporadic neuroblastomas.

Methods

Study of whether centrosome amplification is correlated with ploidy status or MYCN amplification
Immunostain of centrosomes
Fluorescence in situ hybridization for ploidy and MYCN copy numbers in 27 neuroblastomas
Tumors: 8 infant triploid, 9 infant diploid, 10 childhood diploid
Ploidy divergence defined as mixed cell population with trisomy 1, with tetrasomy 1, and/or with pentasomy 1 in diploid tumors, and with tetrasomy 1 and pentasomy 1 in triploid tumors, each >5% of cells

Results

Ploidy divergence in 78% of infant diploid tumors, but not in triploid and childhood diploid tumors
Higher incidences of centrosome amplification in childhood and infant diploid tumors than infant triploid tumors
Only infant diploid tumors showed ploidy divergence, implying cytokinesis failure

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