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Fluoxetine vs placebo for depressive symptoms after stroke: failed randomised controlled trial
International Journal of Geriatric Psychiatry, 08/30/07

Ruddell, M., et al. - Growth in antidepressant prescribing is a well-recognised phenomenon in developed countries. In stroke care, the evidence of effectiveness from systematic reviews is surprisingly weak. We therefore decided to undertake a randomised controlled trial comparing fluoxetine to placebo...Conclusions: In addition to the predicted practical problems of conducting an RCT in an elderly frail population, it became clear that most clinicians are not in equipoise about the value of antidepressant medication despite the lack of strong evidence for its effectiveness