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Arterial [H+] and the ventilatory response to hypoxia in humans: influence of acetazolamide-induced metabolic acidosis
Lung Cellular and Molecular Physiology, 11/05/09

Teppema LJ et al. – The metabolic acidosis was accompanied by a rise in ventilation, a substantial fall in PaCO2 and a parallel leftwards shift of the ventilatory CO2 response curve. In placebo, CO2 induced equal relative increases in hypoxic sensitivity (O2–CO2 interaction) regardless of the way it was defined. Acetazolamide shifted the response line representing the relationship between hypoxic sensitivity and arterial [H+] ([H+a]) to higher values of [H+a] without altering its slope indicating that it did not affect the O2–CO2 interaction. So in contrast to earlier belief CO2 and H+ have separate effects on hypoxic sensitivity.

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