Not All First Seizures Are Created Equally
Epilepsy Currents, 11/02/2009
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Sirven JI – The prognosis of first acute symptomatic seizures differs from that of first unprovoked seizure when the etiology is stroke, TBI, and CNS infection. Acute symptomatic seizures have a higher early mortality and a lower risk for subsequent ... seizure. These differences argue against the inclusion of acute symptomatic seizures as epilepsy.
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Seizure Relapse and Development of Drug Resistance Following Long-term Seizure Remission
Archives of Neurology, 10/14/2009
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Schiller Y et al. – Seizure relapse commonly occurs in patients following long–term seizure remission. Treatment history and duration of epilepsy are predictive risk factors for both seizure ... relapse and development of drug resistance.
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Neonatal seizures
Current Treatment Options in Neurology, 10/28/2009
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Glass HC et al. – Seizures in neonates are common and often suggest a serious underlying brain injury such as hypoxia–ischemia, stroke, or hemorrhage. Prolonged video–electroencephalogram (EEG) is the gold standard for detecting seizures, whereas amplitude&ndash ... seizures. Evidence is increasing that seizures themselves impair brain development, but there is evidence in animal models that commonly used medications are potentially neurotoxic. The authors believe that medical management with a goal of eliminating electrographic and electroclinical seizures is ... probably warranted.
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Neocortical seizure foci localization by means of a directed transfer function method
Epilepsia, 10/23/2009
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Wilke C et al. – Although localization of neocortical–onset seizures is typically challenging, the causal measures employed in this study—namely the directed transfer function—identified generators of ... were highly correlated with the cortical regions identified as the seizure–onset zones by the epileptologists. This technique could prove useful in the identification of seizure–specific propagation pathways in the presurgical evaluation of patients with epilepsy.
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Transient Seizure-Related MRI Abnormalities
Journal of Neuroimaging, 10/12/2009
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Ong B et al. – Reversible edema following seizure activity has been well described; however, there are now a number of further distinct MR findings described in the literature, also documented to be transient and associated with seizure activity. A ... review of these described transient conventional magnetic resonance imaging manifestations of seizure activity is presented in pictorial essay format. In addition to posterior reversible encephalopathy syndrome appearances, less common abnormalities involving the cerebral and cerebellar cortices ... seizure,neuroradiology
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A new understanding of why seizures occur with alcohol withdrawal
EurekAlert, 10/19/2009
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Epileptic seizures are the most dramatic and prominent aspect of the "alcohol withdrawal syndrome" that occurs when a person abruptly stops a long–term or chronic drinking habit. Researchers have shown that the flow of calcium ... voltage–gated calcium channels plays an important role in the generation of alcohol withdrawal seizures, because blocking this flow suppresses these seizures.
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Seizures in the context of acute illness
Current Opinion in Pediatrics, 10/02/2009
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Riviello JJ – The recognition and rapid treatment of clinical and electrographic seizures is important during acute illness.
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Bilateral hippocampal stimulation for intractable temporal lobe epilepsy: Impact on seizures and memory
Epilepsia, 10/21/2009
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McLachlan RS et al. – Seizure frequency decreased by 33% in the two patients during stimulation and remained lower by 25% for the 3 months after stimulation was turned off before returning ... occurred. No other adverse effects occurred. Seizure frequency is reduced both during and for a period after bilateral hippocampal stimulation, but the overall impact in this study is not as robust as has been previously reported.
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Olanzapine-Induced Clinical Seizure: A Case Report
Clinical Neuropharmacology, 10/13/2009
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Behere RV et al. – Electroencephalogram showed epileptiform discharges; results of computed tomographic scan and metabolic investigations were normal. His antipsychotic was changed to haloperidol, and the patient showed a significant ... with no recurrence of seizures and did not require anticonvulsant therapy. Olanzapine has a profile similar to that of clozapine and shares its seizure–inducing potential. Typical antipsychotics such as haloperidol might be a safer option for such patients.
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Sequential intrarectal diazepam and intravenous levetiracetam in treating acute repetitive and prolonged seizures
Epilepsia, 10/29/2009
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Modur PN et al. – These findings suggest that although IRD or IVL monotherapy is efficacious, the combination is superior in controlling ARPS in this special group of ... treatment results in rapid seizure control and fewer ER transfers, despite seizure recurrence.
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