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See Latest ArticlesThe Biology of the (Pro)Renin Receptor
Journal of the American Society of Nephrology, 11/25/09
Nguyen G et al. – The (pro)renin receptor (PRR) binds renin and prorenin, its proenzyme inactive form. Receptor–bound prorenin becomes enzymatically active and binding then activates the MAP kinases ERK1/2 and p38 pathways, leading to upregulation of profibrotic and cyclooxygenase–2 genes independent of angiotensin II generation. These characteristics explain the interest in the potential role of PRR in organ damage in diseases associated with activation of the renin–angiotensin system (RAS), in particular hypertension and diabetes. Although identification of PRR has improved our understanding of the physiology of the tissue RAS, its role in pathology is far from clear.
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