Nephrology Medical News about lymphoblastic leukemia

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Stage-specific Arf tumor suppression in Notch1-induced T cell acute lymphoblastic leukemia
Blood, 09/22/09

Volanakis EJ et al. – Use of cultured thymocyte–derived donor cells expressing a functionally null Arf–GFP knock–in allele confirmed that ICN1 signaling can induce Arf expression in vivo. Arf activation by ICN1 in T cells thereby provides stage–specific tumor suppression but also a strong selective pressure for deletion of the locus in T–ALL.

Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia
Blood, 11/13/09 Relevance Score: 67%

T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics and outcome from the large randomised prospective trial (UKALL XII/ECOG 2993)
Blood, 11/02/09 Relevance Score: 67%

Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia
International Journal of Hematology, 10/13/09 Relevance Score: 67%

Outcome of childhood acute lymphoblastic leukemia with induction failure treated by the Japan Association of Childhood Leukemia Study (JACLS) ALL F-protocol
Pediatric Blood & Cancer, 10/09/09 Relevance Score: 67%

Concurrent intensive chemotherapy and imatinib before and after stem cell transplantation in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Final results of the CSTIBES02 trial
Haematologica, 10/07/09 Relevance Score: 67%