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Platelet-associated complement factor H in normal individuals and patients with atypical HUS
Blood, 08/25/09
Licht C et al. – Washed normal platelets were also observed to take up labelled CFH in vitro. Exposure of washed normal platelets to plasma of an aHUS patient with CFH autoantibodies produced partial platelet aggregation or agglutination, which was prevented by pre–incubation of platelets with purified CFH. This CFH–dependent response did not involve P–selectin mobilization, indicating a complement–induced platelet response distinct from granule secretion.
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