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Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome
Nephrology Dialysis Transplantation, 08/12/09
Strobel S et al. – The results support a direct role of the autoantibodies in aHUS pathology by inhibiting the regulatory function of CFH at cell surfaces and suggest that reduction of the autoantibody titre is beneficial for the patients.
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