Top hus Articles in Nephrology

Lupus nephritis combined with renal injury due to thrombotic thrombocytopaenic purpura-haemolytic uraemic syndrome
Nephrology Dialysis Transplantation, 08/26/2009

ndash; ADAMTS–13 autoantibodies might play an important role in the pathogenesis of TTP–HUS associated with lupus nephritis. The long–term outcome seems to be worse in patients with both TTP–HUS and lupus nephritis than in patients with lupus nephritis alone. [more...]

Hemolytic-uremic syndrome in Switzerland: a nationwide surveillance 1997-2003
European Journal of Pediatrics, 10/19/2009

six with HUS due to invasive Streptococcus pneumoniae infection. Mortality was 5.3%, including two out of six children with S. pneumoniae infection. The severity of thrombocytopenia and the presence of central nervous system involvement significantly correlated with mortality. childhood HUS is not [more...]

Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome
Nephrology Dialysis Transplantation, 08/12/2009

ndash; The results support a direct role of the autoantibodies in aHUS pathology by inhibiting the regulatory function of CFH at cell surfaces and suggest that reduction of the autoantibody titre is beneficial for the patients. [more...]

Ten years of pneumococcal-associated haemolytic uraemic syndrome in New Zealand children
Journal of Paediatrics and Child Health, 10/28/2009

disease remains an important public health problem in New Zealand children, particularly those of Maori and Pacific Island ethnicity. P–HUS should be considered in pneumococcal disease associated with severe haematological and renal abnormalities. These children should be monitored long&ndash [more...]

Severe atypical HUS caused by CFH S1191L--case presentation and review of treatment options
Pediatric Nephrology, 11/04/2009

De S et al. – Eculizumab, a monoclonal humanized anti–C5 antibody, has recently been shown to be effective and well–tolerated in patients with paroxysmal nocturnal hemoglobinuria by [more...]

Platelet-associated complement factor H in normal individuals and patients with atypical HUS
Blood, 08/25/2009

Licht C et al. – Washed normal platelets were also observed to take up labelled CFH in vitro. Exposure of washed normal platelets to plasma of an aHUS patient with CFH autoantibodies produced partial [more...]