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Familial atypical cold urticaria: Description of a new hereditary disease
Journal of Allergy and Clinical Immunology, 11/25/09

Gandhi C et al. – FACU is a new cold–induced inherited disease that is different than ACU in its natural history, atmospheric cold elicitation, severity of systemic reactions, and CSTT results. FACU differs from familial cold autoinflammatory syndrome in symptom timing and the absence of fever, chills, and joint pain. The cause is suspected to be mast cell related. Treatment of reactions is similar to that for ACU. Further evaluation of pathogenesis and genetics is warranted.

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