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Diastolic Function is Reduced in Adolescents With Type 1 Diabetes in Response to Exercise
Diabetes Care, 07/11/2012
Gusso S et al. – Adolescents with type 1 diabetes have reduced exercise capacity and display alterations in cardiac function compared with nondiabetic controls, associated with reduced stroke volume during exercise.
Methods- The study evaluated 53 adolescents with type 1 diabetes and 22 control adolescents.
- Baseline data included peak exercise capacity and body composition by dual-energy X-ray absorptiometry.
- Left ventricular functional parameters were obtained at rest and during acute exercise using magnetic resonance imaging.
- Compared with nondiabetic control subjects, adolescents with type 1 diabetes had lower exercise capacity (44.7 ± 09 vs. 48.5 ± 1.4 mL/kg fat-free mass (FFM)/min; P < 0.05).
- Stroke volume was reduced in the diabetes group at rest (1.86 ± 0.04 vs. 2.05 ± 0.07 mL/kg FFM; P = 0.02) and during acute exercise (1.89 ± 0.04 vs. 2.17 ± 0.06 mL/kg FFM; P = 0.01).
- Diabetic adolescents also had reduced end-diastolic volume at rest (2.94 ± 0.06 vs. 3.26 ± 0.09 mL/kg FFM; P = 0.01) and during acute exercise (2.78 ± 0.05 vs. 3.09 ± 0.08 mL/kg FFM; P = 0.01).
- End-systolic volume was lower in the diabetic group at rest (1.08 ± 0.03 vs. 1.21 ± 0.04 mL/kg FFM; P = 0.01) but not during acute exercise.
- Exercise capacity and resting and exercise stroke volumes were correlated with glycemic control but not with diabetes duration.
